hla typing from serology to sequencing era
نویسندگان
چکیده
the last two decades have seen a massive growth in the application of dna technology in histocompatibility and immunogenetics. this review summarises the history and application of dna methods in this area.
منابع مشابه
HLA typing from Serology to Sequencing Era
The last two decades have seen a massive growth in the application of DNA technology in Histocompatibility and Immunogenetics. This review summarises the history and application of DNA methods in this area.
متن کاملHLA Typing from Serology to Sequencing Era.
The last two decades have seen a massive growth in the application of DNA technology in Histocompatibility and Immunogenetics. This review summarises the history and application of DNA methods in this area.
متن کاملHLA Typing – A Comparison of Serology and DNA Techniques
DNA based HLA typing is fast replacing conventional Microlymphocytotoxicity based method, which has been regarded as the gold standard. Many laboratories in Mumbai have already switched over to molecular methods, as the results are far superior. This study was undertaken to compare the results of generic molecular typing by sequence specific primers (SSP) with that by serology in our laboratory...
متن کاملOptiType: precision HLA typing from next-generation sequencing data
MOTIVATION The human leukocyte antigen (HLA) gene cluster plays a crucial role in adaptive immunity and is thus relevant in many biomedical applications. While next-generation sequencing data are often available for a patient, deducing the HLA genotype is difficult because of substantial sequence similarity within the cluster and exceptionally high variability of the loci. Established approache...
متن کاملHLA typing: Conventional techniques v. next-generation sequencing.
BACKGROUND The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need of an unrelated haematopoietic stem cell transplantation (HSCT). Next-generation sequencing (NGS) has numerous advantages compared with conventional typing techniques. OBJECTIVE...
متن کاملDNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1.
High incidences of graft failure and graft-versus-host disease in the recipients of bone marrow transplantations (BMT) from unrelated donors (URD) may reflect the existence of allelic disparities between the patient and the URD despite apparent HLA identity at HLA-A, HLA-B, and HLA-DRB1 loci. To identify the extent and pattern of allelic disparities at HLA-A and HLA-B loci, 128 patients and 484...
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عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۴، شماره ۲، صفحات ۵۳-۶۶
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